Trichlormethiazide
| Price | $10 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | Ex 20 tons |
| Update Time: | 2022-10-11 |
Product Details
| Product Name: Trichlormethiazide | CAS No.: 133-67-5 |
| EC-No.: 205-118-8 | Min. Order: 1kg |
| Purity: 99% | Supply Ability: Ex 20 tons |
| Release date: 2022/10/11 |
Use of Trichlormethiazide
Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.Target: OthersTrichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic [1-3].
| Name | Trichlormethiazide |
|---|---|
| Synonym | More Synonyms |
| Description | Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.Target: OthersTrichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic [1-3]. |
|---|---|
| Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease |
| Solvent | In Vitro: DMSO : 150 mg/mL (394.05 mM; Need ultrasonic) In Vivo: 1.Add each solvent one by one: 10% DMSO 90% corn oil Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution 2.Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution 3.Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution |
| Solubility | 1 mM2.6270 mL13.1351 mL26.2702 mL5 mM0.5254 mL2.6270 mL5.2540 mL10 mM0.2627 mL1.3135 mL2.6270 mL |
| Storage | 4°C, protect from light |
| Shipping | Room temperature in continental US; may vary elsewhere |
| SMILES | O=S(C1=C(Cl)C=C(C2=C1)NC(C(Cl)Cl)NS2(=O)=O)(N)=O |
| References | [1]. Fuchs, M., B.E. Newman, and R.H. Seller, The clinical pharmacology of trichlormethiazide (Naqua). Curr Ther Res Clin Exp, 1961. 3: p. 116-24. [2]. Reisman, E.E., Jr., Clinical experience with trichlormethiazide in edema. Angiology, 1963. 14: p. 59-63. [3]. West, R.O., A clinical and statistical study of the effect of trichlormethiazide on blood pressure. Med Ann Dist Columbia, 1962. 31: p. 574-7. |
| Related Molecules | EIPA | Riluzole | Ginsenoside Rg3 | Cariporide | Eleclazine hydrochloride | GS967 | Tenapanor | Triamterene | Ranolazine dihydrochloride | PF 05089771 | flecainide acetate | A-803467 | CNV1014802 (hydrochloride) | Zonisamide | Cinchocaine |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 631.3±65.0 °C at 760 mmHg |
| Melting Point | 248-250oC |
| Molecular Formula | C8H8Cl3N3O4S2 |
| Molecular Weight | 380.656 |
| Flash Point | 335.6±34.3 °C |
| Exact Mass | 378.902191 |
| PSA | 135.12000 |
| LogP | 0.24 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.625 |
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