trans-ACPD NEW
| Price | $41 | $91 | $150 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: trans-ACPD | CAS No.: 67684-64-4 |
| Purity: 99.53% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | trans-ACPD |
| Description | trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/15/23/800 μM, mGluR2/1/5/4). |
| In vitro | Excitatory amino acid (EAA) analogues activate receptors linked to increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices from neonatal rats (6-11 days old) characterize the effects of EAA analogues on these receptors. The EC50 value of trans-ACPD is 51 μM, and DL-2-Amino-3-phosphonopropionate (DL-AP3) serves as an equally potent inhibitor of PI hydrolysis induced by ibotenate, quisqualate, and trans-ACPD, with IC50 values ranging from 480 to 850 μM [2]. |
| In vivo | Intrathecal administration of NMDA, kainate, and trans-ACPD, along with the pro-inflammatory cytokines TNF-α or IL-1β, markedly increases biting behavior in mice, a paradigm shift from the control group receiving saline. Pre-systemic intervention with GM at a dosage of 100 mg/kg intraperitoneally notably decreases biting behavior in comparison to saline treatment (10 mL/kg, i.p.), with statistical significance (p<0.001). The efficacy of GM is particularly pronounced against pro-inflammatory cytokines and NMDA, exhibiting inhibition rates of TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). Conversely, kainate-induced biting responses remain unaffected by GM at the same concentration. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 1eq. NaOH : 50 mM H2O : 5 mM, Heating is recommended. |
| Keywords | trans-ACPD | transACPD | Trans-ACP | Metabotropic glutamate receptors | trans ACPD | mGluR | Inhibitor | inhibit |
| Inhibitors Related | IDRA-21 | Topiramate | Decanoic Acid | Urethane | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Piracetam | O-Phospho-L-serine | Memantine hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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