Product Details
| Product Name:
Tirucallol |
CAS No.:
514-46-5 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Tirucallol |
| Description | Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration. |
| In vitro | The effect of CMG neutral extract (25-200 microg/ml) and Tirucallol (0.1-100 microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 4.27 mg/mL (10 mM), Sonication is recommended.
|
| Keywords | antiinflammatory | triterpene | Euphorbia | tetracyclic | inhibit | Tirucallol | Inhibitor | lacteal | latex |
| Inhibitors Related | Tranilast | L-NAME hydrochloride | Mifepristone | Rutin | Dexamethasone acetate | S-Methylisothiourea sulfate | L-Arginine | Nitroarginine | Ethyl cinnamate | Methylene Blue trihydrate | Diallyl disulfide | L-Arginine hydrochloride |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Neuroprotective Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
-
CAS:140898-91-5
$29.00 / 100mg
-
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$9.80/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2020-01-09 |
United States