Thiomyristoyl NEW
| Price | $52 | $70 | $88 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Thiomyristoyl | CAS No.: 1429749-41-6 |
| Purity: 99.13% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Thiomyristoyl |
| Description | Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. |
| Cell Research | Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control. (Only for Reference) |
| In vitro | In a breast cancer mouse model, Thiomyristoyl inhibits SIRT2 and tumor growth, while also reducing the levels of the c-Myc protein. The anticancer effects of Thiomyristoyl are positively correlated with the reduction of c-Myc levels. |
| In vivo | Thiomyristoyl exhibits weak inhibition towards SIRT3/5/6/7. It can reduce the level of c-MYC in cancer cells in vitro, with the extent of c-MYC reduction directly proportional to the cell line’s sensitivity to Thiomyristoyl. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (171.87 mM) Chloroform : Soluble H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Inhibitor | Sirtuin | Thiomyristoyl | inhibit |
| Inhibitors Related | JGB1741 | Sirtinol | Dihydrocoumarin | Resveratrol | SRT 2104 | Nicotinamide riboside | MC3482 | SIRT6-IN-5 | Salvianolic acid B | Fisetin | 3-TYP | Nicotinamide |
| Related Compound Libraries | Highly Selective Inhibitor Library | Histone Modification Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Anti-Diabetic Compound Library | Glutamine Metabolism Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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