Thioflavin T NEW
| Price | $29 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Thioflavin T | CAS No.: 2390-54-7 |
| Purity: 98.08% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Thioflavin T |
| Description | Thioflavin T (Basic Yellow 1) is a widely used dye for visualizing and is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. |
| In vitro | Thioflavin T (ThT), a benzothiazole dye, notably increases in fluorescence when bound to amyloid fibrils, facilitating their diagnosis both ex vivo and in vitro. This fluorescence enhancement is influenced by micelle formation, with ThT micelles—measuring about 3 nm in diameter—visually confirmed along fibrils using atomic force microscopy. These ThT micelles bind to amyloid fibrils, significantly enhancing fluorescence emission. In aqueous solutions at concentrations typical for fluorescence assays (~10-20 μM), ThT exists as micelles, with its critical micellar concentration determined to be 4.0±0.5 μM. As ThT concentration rises above this threshold, more micelles are observed binding along the amyloid fibrils. However, at low pH, ThT micelle formation is disrupted, and fluorescence enhancement upon binding to amyloid fibrils decreases several-fold, especially below pH 3. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 12.5 mg/mL (39.20 mM), Sonication is recommended. DMSO : 50 mg/mL (156.81 mM) |
| Keywords | Inhibitor | Basic Yellow-1 | inhibit | Basic Yellow1 | Thioflavin T |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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