Product Details
| Product Name:
TC11 |
CAS No.:
100823-03-8 |
| Purity:
97.86% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | TC11 |
| 描述 | TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. |
| 體內(nèi)活性 | TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (139.57 mM)
|
| 關(guān)鍵字 | Cyclin dependent kinase | Apoptotic | Mitotic | CLT003 | Inhibitor | Immunomodulatory | TC 11 | CLT 003 | Derivative | TC11 | inhibit | CDK | Bcl-2 Family | TC-11 | Antitumor | Phenylphthalimide | Death | Caspase |
| 相關(guān)產(chǎn)品 | Ribociclib | (S)-(+)-Ibuprofen | Navitoclax | Palbociclib monohydrochloride | Venetoclax | Tauroursodeoxycholate | CASIN | Palbociclib | Sodium Oxamate | Abemaciclib | Dinaciclib | Abemaciclib methanesulfonate |
| 相關(guān)庫(kù) | 銅死亡化合物庫(kù) | 抗胰腺癌化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 激酶抑制劑庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$99.00/1EA |
|
Amikon Limited
|
2018-06-26 |
United States