T3Inh-1 NEW
| Price | $115 | $289 | $478 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: T3Inh-1 | CAS No.: 50440-30-7 |
| Purity: 97% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | T3Inh-1 |
| 描述 | T3Inh-1 is a potent and selective ppGalNAc-T3 inhibitor with IC50 of 7 μM. T3Inh-1 protects against breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in tissue cells and mice without causing any toxic side effects. |
| 體外活性 | METHODS: Breast cancer MDA-MB231 cells were treated with T3Inh-1 (5μM, 24/48 hours) to observe cell proliferation and cell invasion. RESULTS T3Inh-1 was significantly effective, inhibiting migration by >80% and invasion by 98%, but had no significant effect on cell proliferation. [1] |
| 體內(nèi)活性 | METHODS: Mice were injected intraperitoneally with T3Inh-1 and serum cleaved FGF23 levels were measured. Three groups of T3Inh-1 (25 and 50 mg/kg, intraperitoneal injection, 24 hours) were administered and serum cleaved FGF23 levels were measured. RESULTS T3Inh-1 resulted in a robust and statistically significant increase in this ratio at the tested concentrations of 25 and 50 mg/kg, suggesting that T3Inh-1 can mitigate the effects of elevated FGF23 signaling in patients with chronic kidney disease. [1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 4.76 mg/mL (10 mM), Sonication is recommended. |
| 關(guān)鍵字 | T3Inh1 | T3Inh 1 | inhibit | O-glycosylation | Inhibitor | T-3Inh-1 | ppGalNAc-T3 | breast cancer cells | FGF23 | invasion | T3Inh-1 |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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