Product Details
| Product Name:
Strophanthidin |
CAS No.:
66-28-4 |
| Purity:
93% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Strophanthidin |
| Description | Strophanthidin (Strophanthidine) can induce calcium overload in vivo. |
| In vitro | The effect of potassium and rubidium on the electrical and mechanical activity of canine Purkinje fibers were studied in vitro in the presence and absence of strophanthidin. METHODS AND RESULTS: High (5.4mM) K or 2.7 Rb decreased the force of contraction. In the presence of these ions, strophanthidin(Strophanthidine) increased the force of contraction as usual but the onset of arrhythmias was delayed. During the toxic stage of strophanthidin, high K or Rb increased the force of contraction, abolished the arrhythias and improved markedly the action potential. In the presence of calcium overload induced by exposure to a K-poor or Na-free solution, K and Rb induced an increase in force of contraction. And in ventricular muscle these ions relaxed the contracture induced by strophanthidin. CONCLUSIONS: It is concluded that K and Rb (in addition to other mechanisms) exert an antiarrhythmic action by increasing potassium conductance and by reducing the calcium overload induced by strophanthidin. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (61.8 mM)
|
| Keywords | Sodium potassium pump | cardiac | naturally | available | systolic | glycoside | inhibit | Strophanthidin | sarcolemmal | Inhibitor | diastolic | Na+/K+ ATPase |
| Inhibitors Related | Nisoldipine | Diltiazem hydrochloride | Sodium oleate | Levetiracetam | L-Ascorbic acid | Ethyl cinnamate | 1-Octanol | 2-Nitrobenzoic acid | Methyl homoveratrate | Oleic acid | Revaprazan hydrochloride | Otilonium bromide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Covalent Inhibitor Library | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/25kg |
|
Shaanxi Haibo Biotechnology Co., Ltd
|
2023-08-25 |
United States