SAG dihydrochloride NEW
| Price | $59 | $97 | $155 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: SAG dihydrochloride | CAS No.: 2702366-44-5 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | SAG dihydrochloride |
| Description | SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo. |
| In vitro | SAG dihydrochloride, at concentrations ranging from 1-1000 nM for 1 hour, competes with BODIPY-cyclopamine for binding to Smo-expressing Cos-1 cells, resulting in an apparent Kd of 59 nM for the SAG/Smo complex. At doses between 0.1 nM to 100 μM over 30 hours, it activates firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM, but suppresses expression at higher concentrations. Additionally, 100 nM of SAG dihydrochloride counteracts the inhibitory effect of ShhN-induced pathway activation by Robotnikinin. When applied at 250 nM for 24 and 48 hours, it boosts CAXII mRNA levels at 24 hours under both normoxic and hypoxic conditions, and significantly augments SMO mRNA and protein levels at 48 hours in MDAMB231 cells. Furthermore, a 24-hour exposure to 250 nM of SAG enhances migration in MDAMB231 cells. |
| In vivo | SAG dihydrochloride (15-20 mg/kg; i.p.; mice) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice.[4] SAG dihydrochloride (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight week timepoint in CD-1 mice.[5] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 15 mg/mL (26.64 mM), Sonication is recommended. |
| Keywords | SAG Dihydrochloride | SAG | SAG dihydrochloride |
| Inhibitors Related | Itraconazole | Naftifine hydrochloride | GANT 61 | ALLO-2 | Ellagic acid | Triparanol | Vismodegib | BMS-833923 | Ciliobrevin A | Tolnaftate | SAG | SMO-IN-2 |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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