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Postion:Product Catalog >API>Anesthetic Agents>Local anesthetics>Ropivacaine hydrochloride monohydrate
Ropivacaine hydrochloride monohydrate
  • Ropivacaine hydrochloride monohydrate

Ropivacaine hydrochloride monohydrate NEW

Price $32 $48 $72
Package 10mg 25mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Ropivacaine hydrochloride monohydrate CAS No.: 132112-35-7
Purity: 99.80% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameRopivacaine hydrochloride monohydrate
DescriptionRopivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
In vitroRaltitrexed induces double-stranded DNA breaks in a concentration-dependent manner. In Lovo cells and LS174T cell lines containing wild-type p53, Raltitrexed increases the levels of the Bax protein up to 5-fold. In human colon cancer cells, Raltitrexed is actively absorbed into cells and is then rapidly and extensively metabolized into a series of polyglutamates, which results in the effective inhibition of thymidylate synthase. Raltitrexed is delivered to the brain very quickly and can be detected in all brain tissues within 5 minutes. In human colon cancer cells, the combination of Raltitrexed and SN-38 results in a synergistic cytotoxic effect within a range of concentrations. Raltitrexed is a specific folate-based inhibitor of thymidylate synthase. The effect on the activity of advanced rectal cancer is similar to fluorouracil (5-fluorouracil) plus leucovorin. Raltitrexed produces activity by rapid cell entry and glutamination. The glutaminated derivatives are more than 100 times more active than the parent compound. In the HCT-8 cell line, Raltitrexed results in an increase in intracellular phosphoribosyl pyrophosphate (PRPD) indicating that the cytotoxic effect of Raltitrexed in combination with 5-FU is due to increased nucleotide formation of 5-FU. Combinations of Raltitrexed and folinic acid (5FU-FA) show a combination of mode-dependent, synergistic inhibition of proliferation, which is determined by measuring the combination series. Raltitrexed combined with Vorinostat produced significant synergistic effects of cell cycle perturbation and S-phase arrest.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationEthanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 65 mg/mL (197.64 mM), Sonication is recommended.
H2O : 46 mg/mL (147.97 mM)
KeywordsLEA-103 | Potassium Channel | hypertension | Na channels | pain | K(2P) | neuropathic | Inhibitor | vasoconstrictive | KcsA | Ropivacaine hydrochloride Monohydrate | Na+ channels | Ropivacaine HCl Monohydrate | potassium | Ropivacaine hydrochloride monohydrate | Ropivacaine Hydrochloride | TREK-1 | Sodium Channel | inhibit | conduction | Ropivacaine hydrochloride | LEA103 | channel | neuronal
Inhibitors RelatedPhenytoin sodium | Lidocaine hydrochloride | L-Aspartic aicd sodium
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
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