Product Details
| Product Name:
Resiniferatoxin |
CAS No.:
57444-62-9 |
| Purity:
99.12% |
Supply Ability:
10g |
| Release date:
2025/06/17 |
Product Introduction
Bioactivity
| Name | Resiniferatoxin |
| Description | Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE. |
| In vitro | METHODS: RAW264.7 cells were treated with LPS (100 ng/ml) and IFN-γ (3 ng ml?1) and then treated with Resiniferatoxin ((+)-Resiniferatoxin) (0.01, 0.1, 1, 10.24 h). The culture medium was collected for NO determination, and the cell lysates were subjected to SDS-PAGE to measure and quantify iNOS or COX-2 immunoreactivity.
RESULTS At a concentration of 10 μM, Resiniferatoxin ((+)-Resiniferatoxin) inhibited LPS-induced NO production by 67±10% and 52±6%, respectively, and failed to affect LPS-induced COX-2 and PGE2 responses. [3] |
| In vivo | METHODS: Resiniferatoxin ((+)-Resiniferatoxin) (2 μg/10 μl) was injected intrathecally into the T2/T3 space of mice. Cardiac sympathetic nerve activity (CSNA) and cardiac electrophysiology were assessed two weeks later.
RESULTS Intrathecal injection of Resiniferatoxin ((+)-Resiniferatoxin) significantly and selectively eliminated the expression of dorsal horn afferent markers (TRPV1 and calcitonin gene-related peptide) and reduced overactive CSNA. Electrophysiological studies have shown that intrathecal administration of Resiniferatoxin ((+)-Resiniferatoxin) can significantly reverse the prolongation of action potential duration (APD) and APD alternating hormones and reduce the inducibility of ventricular arrhythmias. [4] |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : soluble
|
| Keywords | Th1 cytokine | Resiniferatoxin (From Euphorbia) | Resiniferatoxin | ILReceptor | IL Receptor |
| Inhibitors Related | Inosine pranobex | Apilimod mesylate | Amlexanox | Isosteviol | Dexamethasone acetate | L-Arginine | Bergenin | Dexamethasone | α-Terpineol | Diallyl disulfide | Linalool | Apilimod |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States