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Postion:Product Catalog >PS210
PS210
  • PS210

PS210 NEW

Price $68 $109 $207
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-09

Product Details

Product Name: PS210 CAS No.: 1221962-86-2
Purity: 99.78% Supply Ability: 10g
Release date: 2025/05/09

Product Introduction

Bioactivity

NamePS210
DescriptionPS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1 without affecting other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves as a substrate-selective inhibitor of PDK1 in cells, inhibiting the phosphorylation and activation of S6K.
In vitroPS210 stabilized the residue Arg131 when PS210 causes stabilization of PDK1 to the temperature gradient, located opposite to the helix a-B at the other extreme of the helix a-C. So, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 60 mg/mL (157.77 mM), Sonication is recommended.
KeywordsThr148 | S6K | PS423 | PS-210 | PS210 | PS 210 | pocket | PIFtide | PIF-binding | PDK-1 | PDK1 | Lys76 | Inhibitor | inhibit | helix | Arg131 | a-B
Inhibitors RelatedMP7 | Rabusertib | M77976 | Polyphyllin I | Sodium dichloroacetate | RS1-PDK1 inhibitor | BX795 | Dehydroabiethylamine | Osu03012 | Dicoumarol | PS 48 | PHT-427
Related Compound LibrariesAnti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neuroprotective Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Neuronal Differentiation Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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