Chinese name: Procaine hydrochloride

English name: Procaine hydrochloride

CAS: 51-05-8

EINECS number: 200-077-2

Molecular formula: C13H21ClN2O2

MDL number: MFCD00007893

Molecular weight: 272.77

Appearance: White crystal or crystalline powder, odorless, slightly bitter taste, followed by paralysis. This product is easily soluble in water, slightly soluble in ethanol, slightly soluble in chloroform, insoluble in ether.

Melting point: 155-156 °C(lit.)

Boiling point: 195-196°C 17mm

Density: 1.1761 (rough estimate)

Refractive index: 1.5270 (estimate)

Flash point: 195-196°C/17mm

Storage condition: room temp

Solubility: Solution S is clear (2.2.1) and colourless (2.2.2, Method II).

Form crystal or crystalline powder

Color colorless to white

Water soluble Soluble in water

Sensitivity air sensitivity

Merck14, 7757

BRN3917802

Stable and stable. Incompatible with strong oxidants.

InChIKeyHCBIBCJNVBAKAB-UHFFFAOYSA-N

LogP2.364 (est)

Use 1

Na+ channel blockers or sealers.

intro

Procaine hydrochloride is a local anesthetic, can temporarily block the conduction of nerve fibers and has anesthetic effect, strong effect, low toxicity, and no addiction, but the penetration of skin and mucous membrane is weak, not suitable for surface anesthesia, clinical mainly used for infiltration, spinal and conduction anesthesia.

The aqueous solution of this product is stable between pH3.0 and 5.0. Therefore, when preparing procaine hydrochloride injection, it is generally necessary to add acid to adjust the pH3.3 ~ 5.5, and strictly control the sterilization temperature and time, and it is appropriate to sterilize the steam at 100℃ for 30min, and attention should be paid to shade the light and keep it closed. The aromatic amino group in the structure of this product is combined with sodium nitrite to form diazo salt in dilute hydrochloric acid, and basic β-naphthol is added to produce scarlet azo compound.

nature

Procaine hydrochloride is white fine needle crystal or crystalline powder at room temperature, odorless, slightly bitter and hemp, easily soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. The ester bond in the structure of procaine hydrochloride can be hydrolyzed to produce p-aminobenzoic acid and diethylaminoethanol. Under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline. The structure of procaine hydrochloride has aromatic amino group, easy oxidation discoloration, pH value, temperature, ultraviolet light, oxygen and metal ions can accelerate oxidation discoloration.