Polyoxyethylene stearate NEW
| Price | $64 |
| Package | 10g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Polyoxyethylene stearate | CAS No.: 9004-99-3 |
| Purity: polymer | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Polyoxyethylene stearate |
| Description | Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying. |
| In vitro | Polyoxyethylene stearate modulates P-gp ATPase activity in a concentration-dependent manner, reducing P-gp mediated efflux, notably enhancing the efficacy of substances like vinblastine sulfate by limiting their expulsion from cells. This compound is also recommended to augment the radiolabelled 7H12 Middlebrook TB media, significantly promoting mycobacterial growth in the BACTEC rapid culture system. Its effectiveness extends across various mycobacterial species beyond M. tuberculosis. Specifically, at concentrations of 100 or 150 μg/mL, polyoxyethylene 40 stearate substantially increases the cytotoxicity of vinblastine to K562/ADR cells. Moreover, polyoxyethylene (50) stearate markedly boosts mycobacterial growth rates and decreases detection times in cultures, illustrating its broad potential in enhancing antimicrobial and chemotherapeutic treatments. |
| In vivo | In the combination of polyoxyethylene 40 stearate and vinblastine, there is a significant reduction in both the average tumor volume and weight compared to the vinblastine group alone. The tumor growth inhibition rate markedly increases from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group). Furthermore, polyoxyethylene stearate shows potential as a pharmaceutical excipient to enhance the oral bioavailability of drugs that are substrates for P-glycoprotein (P-gp) and certain cytochrome P450 (CYP) isoforms [2][3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (136.97 mM) |
| Keywords | Cluster of differentiation 243 | CD243 | Bacterial | Polyoxyethylene Stearate | Polyoxyethylene stearate | MDR1 | Inhibitor | Pgp | P-glycoprotein | Multidrug resistance protein 1 | ABCB1 | inhibit | P-gp |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | G-418 disulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/200KG |
VIP3Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2024-11-01 | |
| $10.00/1kg |
VIP6Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2024-10-29 | |
| $0.00/1kg |
VIP2Y
|
Hebei Kingfiner Technology Development Co.Ltd
|
2024-07-03 | |
| $70.00/1kg |
VIP1Y
|
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
2024-05-24 | |
| $18.00/10kg |
VIP1Y
|
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
|
2024-05-11 | |
| $20.00/25kg |
Ouhuang Engineering Materials (Hubei) Co., Ltd
|
2024-04-24 | ||
| $8.00/1KG |
VIP2Y
|
Henan Fengda Chemical Co., Ltd
|
2024-04-09 | |
| $0.00/1kg |
VIP1Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-04-03 | |
| $30.00/1kg |
VIP5Y
|
Hebei Yanxi Chemical Co., Ltd.
|
2023-11-15 | |
| $80.00/1kg |
Hebei Yime New Material Technology Co., Ltd.
|
2023-11-08 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY