Physachenolide C NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Physachenolide C | CAS No.: 791117-61-8 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Physachenolide C |
| Description | Physachenolide C, a selective BET inhibitor, induces apoptosis and arrests the cell cycle at the G0-G1 phase, exhibiting antitumor activity [1]. |
| In vitro | Physachenolide C, at concentrations ranging from 0.01-10 μM over a 48-hour period, impedes the proliferation of Yale University Mouse Melanoma (YUMM) cell lines YUMM2.1 and YUMMER1.7, exhibiting half-maximal inhibitory concentration (IC50) values of 0.5159 μM and 1.8230 μM, respectively. Concurrently, this compound markedly elevates the population of early-stage apoptotic cells and induces cell cycle arrest at the G0-G1 phase [1]. |
| In vivo | Physachenolide C, administered intratumorally at a dose of 20 mg/kg daily for 15 consecutive doses, markedly suppressed tumor growth and induced complete regression of tumors in a murine melanoma model, without notable toxicity in the mice. Furthermore, treatment with Physachenolide C resulted in a significant elevation in the proportion of TUNEL-positive cells, reaching 40%, indicating enhanced apoptotic activity [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | ABBV-744 | CeMMEC1 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | (+)-JQ-1 | J-147 | Curcumin | dBET6 | Piflufolastat | Naphthol AS-E | Bisdemethoxycurcumin |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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