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Postion:Product Catalog >Phthalazinone pyrazole
Phthalazinone pyrazole
  • Phthalazinone pyrazole

Phthalazinone pyrazole NEW

Price $58 $88 $148
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: Phthalazinone pyrazole CAS No.: 880487-62-7
Purity: 97.03% Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

名稱Phthalazinone pyrazole
描述Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity.
體外活性Phthalazinone pyrazole potently inhibited the activity of Aurora A kinase with an IC50 of 31 nM. It showed no inhibitory effect on Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibited the proliferation of HCT116, Colo205, and MCF-7 cells with IC50 values of 7.8, 2.9, and 1.6 μM, respectively [1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : Slightly soluble
關(guān)鍵字inhibit | human embryonic stem cells | Aurora Kinase | hepatocyte-like cell | Inhibitor | HLCs | Aurora-A kinase | EMT | apoptosis | Phthalazinone pyrazole | tumor growth | oral | epithelial-mesenchymal transition
相關(guān)產(chǎn)品Palmatine chloride | MK-8745 | SC-514 | Barasertib-HQPA | MBM-55S | SP600125 | KW-2449 | Palmatine | Alisertib | TAK-901 | Tozasertib | TCS7010
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | 表觀遺傳庫(kù) | 激酶抑制劑庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 口服活性化合物庫(kù) | 已知活性化合物庫(kù) | 細(xì)胞周期化合物庫(kù) | 抗癌化合物庫(kù) | 抗癌活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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