Product Details
| Product Name:
Peretinoin |
CAS No.:
81485-25-8 |
| Purity:
99.86% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Peretinoin |
| Description | Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR. |
| Cell Research | Cell Line: Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line. Concentration: 5 μM. Incubation Time: 24 hours [2] |
| In vitro | Peretinoin (10-40 μM; 12-72 hours) exhibits suppressed SPHK1 expression after 24 h treatment, even at 10 μM and more prominent after 72 h peretinoin treatment [1]. Peretinoin (5 μM; 24 hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes [2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with an EC50 of 9 μM [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (148.78 mM), Sonication is recommended.
|
| Keywords | inhibit | Retinoic acid receptors | SphK | Retinoid X receptors | HCV | Inhibitor | NIK 333 | Peretinoin | Autophagy | Sphingosine kinase | NIK-333 | Hepatitis C virus | RAR/RXR |
| Inhibitors Related | Stavudine | Xylitol | Myricetin | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:246857-26-1
$0.00 / 5mg
-
-
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$8.00/1KG |
VIP5Y
|
Career Henan Chemica Co
|
2020-10-27 |
United States