Omarigliptin NEW
| Price | $34 | $48 | $77 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Omarigliptin | CAS No.: 1226781-44-7 |
| Purity: 99.70% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Omarigliptin |
| Description | Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. [3] |
| In vitro | METHODS: HrGECs cells were stimulated with 0, 1, 2, 10, 20, 100 and 200 μM Omarigliptin for 24 hours and cell viability was observed. RESULTS When the concentration of Omarigliptin was 100 and 200 μM, the viability of HrGECs cells decreased significantly. [2] |
| In vivo | METHODS: A diabetic mouse model was established by treating with streptozotocin (STZ). Omarigliptin (2.5, 5 mg/kg, oral) was used to investigate the effects of Omarigliptin on glucose and insulin levels, cognitive dysfunction, oxidative stress, SIRT3 and FOXO3a expression, and NAD/NADH activity in STZ-induced diabetic mice. RESULTS Omarigliptin can significantly reduce blood glucose in STZ-induced diabetic mice, accompanied by increased serum insulin levels; Omarigliptin improves cognitive dysfunction in STZ-induced diabetic mice; Omarigliptin treatment rescues GSH in the hippocampus in a dose-dependent manner; Omarigliptin induces increased SIRT3 expression and prevents FOXO3a acetylation. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (125.49 mM) |
| Keywords | Omarigliptin | inhibit | glucagon like peptide-1 | anti-parkinsonian | Dipeptidyl Peptidase | blood-brain barrier | MK 3102 | DPP | orally active | Inhibitor | MK3102 | anti-diabetic |
| Inhibitors Related | Sitagliptin | Sitagliptin phosphate monohydrate | Linagliptin | Vildagliptin | Alloxan monohydrate | 4'-Hydroxychalcone |
| Related Compound Libraries | Highly Selective Inhibitor Library | Glycometabolism Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Inhibitor Library | NO PAINS Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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