NSC 228155 NEW
| Price | $43 | $43 | $61 | $61 | $127 | $127 |
| Package | 5mg | 5mg | 10mg | 10mg | 25mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: NSC 228155 | CAS No.: 113104-25-9 |
| Purity: 99.84% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | NSC 228155 |
| Description | NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulating EGFR tyrosine phosphorylation. |
| Cell Research | MDA MB468 cells serum-starved overnight are pre-incubated (or not) with 10?μM AG1478 or 2?μM PD 153035 for 90?min and then, where indicated, incubated with 100?μM NSC 228155 or CN 009543V or 150?ng/ml EGF or vehicle (0.2% DMSO) for 15?min. Proteins are blotted to nitrocellulose membrane and analyzed with biotinylated anti-pTyr P100, anti-pEGFR Y1068 and anti-EGFR (epitope in cytoplasmic region) antibodies. (Only for Reference) |
| In vitro | NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 12 mg/mL (41.3 mM) |
| Keywords | NSC 228155 | Epidermal growth factor receptor | NSC-228155 | Histone Acetyltransferase | EGFR | HER1 | HATs | inhibit | Inhibitor | HAT | Epigenetic Reader Domain | ErbB-1 |
| Inhibitors Related | Rifampicin | 5-Fluorouracil | Acetaminophen | Ribavirin | Guanidine hydrochloride | 2,4-D | Curcumin | Thymidine | Naphthol AS-E | Gefitinib | Temozolomide | Folic acid |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Anti-Prostate Cancer Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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