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Postion:Product Catalog >NS309
NS309
  • NS309

NS309 NEW

Price $52 $63 $122
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: NS309 CAS No.: 18711-16-5
Purity: 95.87% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameNS309
DescriptionNS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 45 mg/mL (194.77 mM), Sonication is recommended.
KeywordsPotassium Channel | SCI/R | spinal | neuronal | NS 309 | overactive | erectile | OAB | function | KcsA | NS309 | NS-309 | Inhibitor | ischemia-reperfusion | bladder | cord | hyperexcitability | inhibit | injury
Inhibitors RelatedMinoxidil sulfate | Osimertinib | Lapatinib | Halothane | Erlotinib hydrochloride | Erlotinib | Neratinib | Cloperastine hydrochloride | Genistein | Gefitinib | 2,2,2-Trichloroethanol | Indapamide
Related Compound LibrariesReprogramming Compound Library | Anti-Pancreatic Cancer Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library | Ion Channel Targeted Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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