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Postion:Product Catalog >N,N'-DINITROSOPIPERAZINE
N,N'-DINITROSOPIPERAZINE
  • N,N'-DINITROSOPIPERAZINE
  • N,N'-DINITROSOPIPERAZINE

N,N'-DINITROSOPIPERAZINE NEW

Price $6 $5 $1
Package 1KG 25KG 100KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: N,N'-DINITROSOPIPERAZINE CAS No.: 140-79-4
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express Origin: Manufacturer
Name: Sun

1. Product information

Names

Name1,4-Dinitrosopiperazine
SynonymMore Synonyms

 N,N'-Dinitrosopiperazine Biological Activity

DescriptionN,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[1].
Related Catalog
Research Areas >> Cancer
Signaling Pathways >> Others >> Others
In VitroN,N'-Dinitrosopiperazine (0.5-100 μM; 48 hours) has no inhibitory effects on the labeled 6-10B cells, and LDH activity is not significantly altered by DNP treatment in the 0.5-8 μM concentration range. However, it is cytotoxic from the concentration 10 μM[1]. N,N'-Dinitrosopiperazine (2-8 μM; 24 hours) induces 6-10B cell invasion and motility in a dose-dependent manner. At 6 μM, when compares to the control group, DNP increases cell invasion at 421.7% and cell motility is increased by 328.2%[1]. N,N'-Dinitrosopiperazine (6 μM; 24 hours) increases the expression of phospho-LYRIC s568 and LYRIC expression in CNE1 cells[1]. Cell Viability Assay[1] Cell Line: The labeled 6-10B cells Concentration: 0.5, 1, 2, 4, 6, 8, 10, 20, 40, 80, or 100 μM Incubation Time: 48 hours Result: Had no inhibitory effects at the concentration 0-8 μM. Western Blot Analysis[1] Cell Line: The NPC cell line CNE1 Concentration: 6 μM Incubation Time: 24 hours Result: Increased phospho-LYRIC s568 and LYRIC expression.
In VivoN,N'-Dinitrosopiperazine (injected into the tail veins; 40 mg/kg; 30 days) inhibits cell motility and invasion, and facilitates NPC metastasis in vivo. From a IHC result, Phospho-LYRIC expression is higher in the metastatic tumors of DNP-treated mice than in those of the untreated control mice[1]. Animal Model: BABL/c nude mice injected with labeled 6-10B cell suspensions (1?×?104 cells) with or without DNP(40 mg/kg)[1] Dosage: 40 mg/kg Administration: Injected into the tail veins; 30 days Result: Induced LYRIC phosphorylation at serine 568 associated with NPC metastasis in vivo.
References

[1]. Damao Huang, et al. Identification of Novel Signaling Components in N,N'-dinitrosopiperazine-mediated Metastasis of Nasopharyngeal Carcinoma by Quantitative Phosphoproteomics. BMC Cancer. 2014 Apr 5;14:243.

 Chemical & Physical Properties

Density1.5±0.1 g/cm3
Boiling Point406.1±38.0 °C at 760 mmHg
Molecular FormulaC4H8N4O2
Molecular Weight144.132
Flash Point199.4±26.8 °C
Exact Mass144.064728
PSA65.34000
LogP-0.88
Vapour Pressure0.0±0.9 mmHg at 25°C
Index of Refraction1.648

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • TL6300000

  • CHEMICAL NAME :

  • Piperazine, 1,4-dinitroso-

  • CAS REGISTRY NUMBER :

  • 140-79-4

  • BEILSTEIN REFERENCE NO. :

  • 0135106

  • LAST UPDATED :

  • 199701

  • DATA ITEMS CITED :

  • 38

  • MOLECULAR FORMULA :

  • C4-H8-N4-O2

  • MOLECULAR WEIGHT :

  • 144.16

  • WISWESSER LINE NOTATION :

  • T6N DNTJ ANO DNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 160 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 160 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 100 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 1040 mg/kg/1Y-I

  • TOXIC EFFECTS :

  • Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 1070 mg/kg/53W-I

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 140 mg/kg female 15-21 day(s) after conception

  • TOXIC EFFECTS :

  • Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Blood - leukemia

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 1568 mg/kg/28W-C

  • TOXIC EFFECTS :

  • Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 720 mg/kg/72W-I

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 1800 mg/kg/64W-C

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 1100 mg/kg/110W-I

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 2250 mg/kg/50W-I

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 7300 mg/kg/52W-C

  • TOXIC EFFECTS :

  • Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 560 mg/kg/10W-C

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 300 mg/kg

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 1086 mg/kg/69W-I

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Gastrointestinal - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 5280 mg/kg/44W-I

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 1120 mg/kg/20W-C

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

  • TYPE OF TEST :

  • TD - Toxic dose (other than lowest)

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 1680 mg/kg/30W-C

  • TOXIC EFFECTS :

  • Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 140 mg/kg

  • SEX/DURATION :

  • female 15-21 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - live birth index (measured after birth)

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 400 mg/kg

  • SEX/DURATION :

  • lactating female 20 day(s) post-birth

  • TOXIC EFFECTS :

  • Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

  • TYPE OF TEST :

  • Specific locus test

  • TYPE OF TEST :

  • DNA damage

  • TYPE OF TEST :

  • Unscheduled DNA synthesis

  • TYPE OF TEST :

  • DNA inhibition

  • TYPE OF TEST :

  • DNA inhibition

  • TYPE OF TEST :

  • Cytogenetic analysis

MUTATION DATA

  • TYPE OF TEST :

  • Host-mediated assay

  • TEST SYSTEM :

  • Rodent - mouse Bacteria - Salmonella typhimurium

  • DOSE/DURATION :

  • 10 mg/kg

  • REFERENCE :

  • CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,4572,1977

 Safety Information

HS Code2933599090

 Synthetic Route

Previous 1/6 Next
Article illustration

Piperazine

110-85-0

~99%

Article illustration

N,N'-Dinitr...

140-79-4

Literature: Borikar, Sanjay P.; Paul, Vincent Synthetic Communications, 2010 , vol. 40, # 5 p. 654 - 660
Article illustration

Piperazine

110-85-0

~83%

Article illustration

1-Nitrosopipera...

5632-47-3

Article illustration

N,N'-Dinitr...

140-79-4

Literature: Tetrahedron Letters, , vol. 44, # 16 p. 3345 - 3349
Article illustration

N,N'-Dimeth...

106-58-1

~89%

Article illustration

N,N'-Dinitr...

140-79-4

Literature: Boyer, Joseph H.; Kumar, Govindarajulu; Pillai, T. Perumal Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1751 - 1754

 Precursor & DownStream

Precursor  8

Previous 1/2 Next

  • Article illustration CAS#:110-85-0
    Piperazine

  • Article illustration CAS#:106-58-1
    N,N'-Dimethylpi...

  • Article illustration CAS#:49860-76-6
    1-ethyl-4-methy...

  • Article illustration CAS#:16339-07-4
    Piperazine,1-me...

DownStream  2



  • Article illustration CAS#:106-59-2
    1,4-Piperazined...

  • Article illustration CAS#:110-85-0
    Piperazine

 Customs

HS Code2933599090
Summary2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

EINECS 205-434-6
NN'-Dinitrosopiperazine
Piperazine, 1,4-dinitroso-
1,4-Dinitrosopiperazine



2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                     Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137





Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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