Product Details
| Product Name:
MDR-1339 |
CAS No.:
1018946-38-7 |
| Purity:
98.57% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | MDR-1339 |
| Description | MDR-1339 (DWK-1339) is an orally active, blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation. |
| In vitro | MDR-1339 shows no significant inhibition of a panel of CYP isozymes, while it slightly inhibits CYP2C8 (IC50: 31.4 μM). MDR-1339 (1.5-10 μM) protects cells from this Aβ-induced toxicity. MDR-1339 (3.1-50 μM) also dose-dependently blocks the formation of Aβ aggregates and disaggregates Aβ fibrils. |
| In vivo | MDR-1339 (0.1-10 mg/kg, p.o.) dose-dependently restores passive avoidance responses in Alzheimer's disease mice models (ED50: 0.19 mg/kg) and significantly improves spontaneous alternation while reducing Aβ1-40 and Aβ1-42 levels in APP/PS1 mice at 30 and 100 mg/kg, p.o. daily for 8 weeks. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 40 mg/mL (122.55 mM), Sonication is recommended.
|
| Keywords | inhibit | β-amyloid peptide | Inhibitor | DWK1339 | MDR 1339 | Abeta | Amyloid-β | MDR1339 | DWK 1339 | MDR-1339 |
| Inhibitors Related | Anle138b | Notoginsenoside R1 | Geniposide | Deferoxamine Mesylate | Valproic acid sodium salt | Tramiprosate | Dihydroergocristine mesylate | Rutin | Valproic Acid | CB-103 | Carvacrol | Methyl tridecanoate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | Orally Active Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$67.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States