Malotilate NEW
| Price | $31 | $48 | $68 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-19 |
Product Details
| Product Name: Malotilate | CAS No.: 59937-28-9 |
| Supply Ability: 10g | Release date: 2025/05/19 |
Product Introduction
Bioactivity
| Name | Malotilate |
| Description | Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis. |
| In vitro | Malotilate caused a significant decrease in the invasion of C-SST-2 cells in RLE monolayers.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation. By enhancing the intercellular contact of endothelial cells, Malotilate prevented the invasion of tumor cells into the vascular endothelium and inhibited tumor metastasis. In multilayer cultures, Malotilate (0.1-100 μM) concentration-dependently increased collagenase activity but did not affect monolayer cells. In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, also without affecting monolayer cells. |
| In vivo | Malotilate caused a significant decrease in the invasion of C-SST-2 cells in RLE monolayers.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation. By enhancing the intercellular contact of endothelial cells, Malotilate prevented the invasion of tumor cells into the vascular endothelium and inhibited tumor metastasis. In multilayer cultures, Malotilate (0.1-100 μM) concentration-dependently increased collagenase activity but did not affect monolayer cells. In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, also without affecting monolayer cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 58 mg/mL (201.12 mM), Sonication is recommended. DMSO : 55 mg/mL (190.72 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | synthesis | oral | NKK-105 | NKK105 | migration | Malotilate | LOX | Lipoxygenase | injury | Inhibitor | inhibit | hepatotropic | collagen | cell | anti-fibrotic | 5-Lipoxygenase |
| Inhibitors Related | 2,5-Di-tert-butylhydroquinone | Caffeic Acid | 5-LOX inhibitor | Diethylcarbamazine citrate | Setileuton | Phenidone | Abietic Acid | Resveratrol | NNK | PF-4191834 | 5-Aminosalicylic Acid | KKII5 |
| Related Compound Libraries | Ferroptosis Compound Library | FDA-Approved & Pharmacopeia Drug Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Approved Drug Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Metabolism Compound Library | Lipid Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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