Product Details
| Product Name:
Izonsteride |
CAS No.:
176975-26-1 |
| Purity:
99.55% |
Supply Ability:
10g |
| Release date:
2024/11/08 |
Product Introduction
Bioactivity
| 名稱 | Izonsteride |
| 描述 | Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is used in the treatment of oncology and genitourinary disorders, and may be used in the study of prostate cancer. |
| 體外活性 | Izonsteride is a benzoquinolinone (BQ) that inhibits 5alpha-R activity in human scalp skin (Ki(typeI)=28.7+/-1.87 nM) and prostatic homogenates (Ki(typeII)=10.6+/-4.5 nM). Lineweaver-Burk, Dixon, and non-linear analysis methods were used to evaluate the kinetics of 5alpha-R inhibition by Izonsteride. Non-linear modeling of experimental data evaluated V(max) in the presence or absence of Izonsteride. Experimental data modeled to the following equation 1v=+ fixing the In0c value equal to 1.0 or 0 are consistent with non-competitive or competitive inhibition, respectively. Izonsteride is a competitive inhibitor of type I 5alpha-R (In0c=0, Ki=3.39+/-0.38, RMSE = 1.300) and a non-competitive inhibitor of type II 5alpha-R (In0c=1, Ki=29. 7+/-3.4, RMSE = 0.0592). These data are in agreement with the linear transformation of the data using Lineweaver-Burk and Dixon analyses. These enzyme kinetic data support the contention that the BQ Izonsteride is a potent dual inhibitor with differing modes of activity against the two known human 5-alpha-reductase isozymes. Izonsteride represents a class of non-steroidal 5alpha-R inhibitors with potential therapeutic utility in treating a variety of androgen-dependent disorders.[1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 6.88 mg/mL (16.27 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Izonsteride | LY 320236 |
| 相關(guān)產(chǎn)品 | Epalrestat | 2-Chloro-1-(4-fluorobenzyl)benzimidazole | Lidorestat | Isoliquiritigenin | Dutasteride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:122110-53-6
$166.00 / 500mg
-
CAS:112856-44-7
$75.00 / 1mg
-
CAS:1354744-91-4
$40.00 / 5mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States