IPI-3063 NEW
| Price | $39 | $58 | $106 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: IPI-3063 | CAS No.: 1425043-73-7 |
| Purity: 99.08% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | IPI-3063 |
| Description | IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM). |
| In vitro | IPI-3063 is a p110δ selective compound with an IC50=0.1?nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher (IC50=1901±1318 nM for p110α, IC50=102.8±35.7 nM for p110β, IC50=418.8±117.2 nM for p110γ). IPI-3063 is very effective in reducing p-AKT (significant effect at 1?nM) and it also decreases p-ERK1/2 with a significant effect at 10?nM. IPI-3063 is very effective, achieving a significant decrease in B cell survival when present at 10?nM and it also inhibits p110α, p110β, and p110γ (IC50s: 1171±533 nM, 1508±624 nM, and 2187±1529 nM, respectively). IPI-3063 effectively decreases mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 83.33 mg/mL (182.94 mM) |
| Keywords | Inhibitor | Phosphoinositide 3-kinase | inhibit | IPI3063 | IPI 3063 | IPI-3063 | PI3K |
| Inhibitors Related | Myricetin | Erucic acid | Sapanisertib | (2S,3R,4S)-4-Hydroxyisoleucine | Duvelisib (R enantiomer) hydrochloride | Isoprenaline hydrochloride | Quercetin | GDC0084 | Quercetin Dihydrate | Apilimod | LY294002 | Idelalisib |
| Related Compound Libraries | Highly Selective Inhibitor Library | Anti-Lung Cancer Compound Library | Neural Regeneration Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Inhibitor Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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