IDRA-21 NEW
| Price | $38 | $59 | $157 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: IDRA-21 | CAS No.: 22503-72-6 |
| Purity: 99.73% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | IDRA-21 |
| Description | IDRA-21 is a positive AMPA receptor modulator. |
| In vivo | Oral administration of IDRA 21 produced a highly significant improvement in the performance of a delayed matching-to-sample (DMTS) task by young adult rhesus monkeys.?The pattern of task improvement over the dose range 0.15-10 mg/kg was maintained to 48 hr after the single dose administration.?For sessions run after administration of the individualized Best Dose of IDRA 21, task accuracy for Long delay (most difficult) trials was increased by 34% of vehicle.?Animals were randomly assigned fixed doses of IDRA 21 to determine whether the positive mnemonic response could be maintained.?The repeated doses were separated by 3 days, thus allowing for potential cumulative effects.?IDRA 21 produced a gradual increase in task accuracy that was maintained on average above vehicle performance levels over an intermittent dosing schedule during a total period of 3 weeks.?A separate group of aged monkeys (>20 y) were, as a group, impaired (during vehicle testing) in DMTS performance efficiency relative to the young cohort.?IDRA 21 also improved task accuracy by aged rhesus monkeys over the same dose range, but the responses were not as robust as those exhibited by young animals.?Aged subjects also appeared to be more individually sensitive to drug dose, and they exhibited shorter task latencies than did the young group[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (107.44 mM) |
| Keywords | memory | Inhibitor | IDRA 21 | inhibit | orally active | Ionotropic glutamate receptors | aging | excitatory neurotransmission | cognitive | IDRA-21 | GluR1/2 | AMPA | IDRA21 | iGluR |
| Inhibitors Related | Topiramate | Decanoic Acid | Urethane | L-Cysteic acid monohydrate | Evans blue | Fenobam | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Piracetam | O-Phospho-L-serine | Memantine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Alzheimer's Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Glutamine Metabolism Compound Library | Neurotransmitter Receptor Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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