HOIPIN-1 NEW
| Price | $195 | $465 | $679 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: HOIPIN-1 | CAS No.: 2470242-33-0 |
| Purity: 98.83% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | HOIPIN-1 |
| Description | HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-kB activation. |
| In vitro | In the HTRF-based analysis of LUBAC-mediated ubiquitination using Petit-LUBAC, the preincubation time of HOIPIN-1 (0.9-120 μM) in the reaction buffer correlates with increased inhibitory activity. The IC50 values at 1 h, 3 h, 6 h, and 24 h are 26 μM, 26 μM, 26 μM, and 3.926 μM, respectively[1]. Co-expression of LUBAC subunits in HEK293T cells increases the level of intracellular linear polyubiquitin chains. HOIPIN-1 (1-30 μM) dose-dependently inhibits the production of intracellular linear polyubiquitin chains in HEK293T cells expressing LUBAC[1]. In HeLa cells, HOIPIN-1 (30-100 μM; 30-60 minutes) inhibits IL-1β-induced NF-κB activation and reduces the phosphorylation of IKKα/β, p105, and p65. Furthermore, at doses of 10-100 μM, HOIPIN-1 dose-dependently inhibits the expression of NF-κB target genes such as ICAM1 and TNF-α induced by IL-1β in HeLa cells[1]. The linear ubiquitin chain assembly complex (LUBAC) consists of HOIL-1L, HOIP, and SHARPIN subunits. HOIPIN-1 inhibits the linear polyubiquitination activity of the HOIL-1L/HOIP complex, HOIL-1L/HOIP/SHARPIN complex, and HOIP/SHARPIN complex with IC50 values of 4.4 μM, 3.5 μM, and 3.7 μM, respectively[2]. In A549 cells, HOIPIN-1 (1-100 μM; 72 hours) shows no apparent cytotoxicity based on ATP content. However, it exhibits cytotoxicity in A549 cells with an IC50 > 100 μM[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.33 mg/mL (10.96 mM), Sonication is recommended. |
| Inhibitors Related | Sodium Houttuyfonate | Zingerone | Lidocaine | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide | Caffeic Acid Phenethyl Ester | Sodium salicylate |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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