Product Details
Product Name:
Hibifolin |
CAS No.:
55366-56-8 |
Purity:
98.92% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | Hibifolin |
Description | Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity. |
In vitro | the inhibitory activity of a plant flavonoid, hibifolin on ADA is investigated using enzyme kinetic assay and isothermal titration calorimetry.?The inhibitory constant of hibifolin was found to be 49.92μM 3.98 and the mode of binding was reversible.?Isothermal titration calorimetry showed that the compound binds ADA with binding energy of -7.21Kcal/mol.?The in silico modeling and docking studies showed that the bound ligand is stabilized by hydrogen bonds with active site residues of the enzyme.?hibifolin can act as a potential inhibitor of ADA. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 55 mg/mL (111.25 mM)
|
Keywords | Adenosine Deaminase | Hibifolin | adenosine | anti-proliferative | anti-inflammatory | neurotoxicity | Inhibitor | deaminase | inhibit |
Inhibitors Related | 3’-O-Methyladenosine | 8-Azaadenosine | Pentostatin | Erdosteine | EHNA hydrochloride | Cladribine |
Related Compound Libraries | Flavonoid Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Saccharide and Glycoside Natural Product Library | Neuroprotective Compound Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$1.00/1mg |
|
Chengdu GLP biotechnology Co Ltd
|
2019-05-13 |