Product Details
| Product Name:
Hesperin |
CAS No.:
4430-35-7 |
| Purity:
98% |
Supply Ability:
10g |
| Release date:
2024/11/21 |
Product Introduction
Bioactivity
| Name | Hesperin |
| Description | Hesperin (6-MSITC), a flavonoid isolated from orange peel, is a circadian decapping enzyme in plants, inhibiting lipid accumulation and production of reactive oxygen and nitrogen species in 3T3-L1 and RAW264.7 cells. |
| In vitro | b>METHODS: HUVEC cells were stimulated with TNF-a or thrombin in the presence of Hesperin (0.03, 0.1, 0.3, 1 μg/ml, 4 hours). The effect of Hesperin on VWF release induced by TNF-a and thrombin was studied.
RESULTS: Hesperin slightly increased TNF-a-induced TF activity, but at 1 lg/mL (4.88 μM), Hesperin reduced TNF-a- or thrombin-induced TF activity; Hesperin did not change the TF activity of unstimulated HUVECs; indicating that TF activity is inversely proportional to the concentration of Hesperin. [2] |
| In vivo | b>METHODS: Wild-type and Nrf2-deficient mice were fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus hesperin (10 mg/kg, ip, daily), 4) HFD for 6 weeks followed by HFD supplemented with iron for 6 weeks (HFD/iron), and 5) HFD/iron plus hesperin; to investigate whether hesperin could improve hepatic steatosis and iron accumulation.
RESULTS: HFD increased hepatic triglycerides in both genotypes and Hesperi; hesperin suppressed the increase in hepatic triglycerides in wild-type mice but did not reduce triglycerides in Nrf2-deficient mice; hesperin did not block hepatic iron accumulation in either genotype. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (121.75 mM), Sonication is recommended.
|
| Keywords | Hesperin |
| Inhibitors Related | (±)-Catechin | Allopurinol | Acetylcysteine | Tempol | Inosine | Lycopene | Ethyl cinnamate | Baicalein | Rifamycin S | Gallic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States