Product Details
| Product Name:
GSK2593074A |
CAS No.:
1337531-06-2 |
| Purity:
100% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | GSK2593074A |
| Description | GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3. |
| In vitro | GSK2593074A (GSK'074) (0.01, 0.1, 1, 10, and 100 nM; 6 h) fully prevents necroptosis across various stimuli in both human and murine cells with IC50~3 nM, including MOVAS cells and L929 cells.[1] |
| In vivo | GSK2593074A (GSK'074) (0.93 mg/kg/day; i.p.; 14 or 28 days; mice) show significantly alleviated aneurysm formation, reflected by a much smaller aortic dilatation (36.28±5.76%; P<0.05) as well as a reduced abdominal aortic aneurysm (AAA) incidence (from 83.3 to 16.7%). GSK2593074A significantly decreases the extent of aortic expansion (27.36±8.25%; P<0.05). Inhibited aneurysm formation in mouse models of aneurysms.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 41.67 mg/mL (89.50 mM), Sonication is recommended.
|
| Keywords | GSK2593074A | GSK-2593074A |
| Inhibitors Related | Cepharanthine | Acetylcysteine | Oditrasertib | Acefylline | Glucosamine | Thalidomide | Taurochenodeoxycholic Acid | Apremilast | Pomalidomide | Lenalidomide | Fisetin | Linalool |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$116.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States