Product Details
| Product Name:
Golidocitinib |
CAS No.:
2091134-68-6 |
| Purity:
98.87% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Golidocitinib |
| Description | Golidocitinib (AZD4205) is a selective JAK1 inhibitor with an IC50 of 73 nM, while it weakly inhibits JAK2 and JAK3 with IC50 values greater than 14.7 μM and 30 μM, respectively. |
| In vitro | AZD4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50: 161 nM). |
| In vivo | AZD4205, administered orally at doses of 12.5 mg/kg, 25 mg/kg, or 50 mg/kg twice daily (BID), exhibits dose-dependent antitumor effects when used alone. Additionally, it boosts the antitumor efficacy of osimertinib when compared to the administration of osimertinib alone in mice implanted with NCI-H1975 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 250 mg/mL (510.65 mM), Sonication is recommended.
|
| Keywords | AZD-4205 | Janus kinase | JAK | AZD 4205 | Inhibitor | Golidocitinib | inhibit |
| Inhibitors Related | Delgocitinib | Deucravacitinib | Fedratinib | RO8191 | Ruxolitinib | Tofacitinib Citrate | CEP-33779 | Ruxolitinib phosphate | JAK-IN-10 | Baricitinib | Tofacitinib | Ritlecitinib |
| Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$97.00/2mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States