Product Details
| Product Name:
Girinimbine |
CAS No.:
23095-44-5 |
| Purity:
99.22% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Girinimbine |
| Description | Girinimbine (Girinimbin) is a carbazole alkaloid isolated from the plants M. koenigii, M. koenigii, and Murraya koenigii. Girinimbine exhibits a wide range of biological effects, including apoptosis, antitrypanosomal, antiplatelet, antimicrobial, anti-inflammatory, antioxidant, and antitumor activities. |
| In vitro | Girinimbine (1-400 μM; 24-72 h; HepG2 cells) demonstrates IC50 values of 61 μM, 56 μM, and 40 μM, reducing HepG2 cell viability at 24, 48, and 72 hours, respectively.[1] Additionally, Girinimbine (10-100 μM; 24-48 h; HepG2 cells) increases LDH leakage in a concentration- and time-dependent manner.[1] With Girinimbine (56 μM; 24-48 h; HepG2 cells) treatment, DNA fragmentation and elevated caspase-3 levels are observed.[1] Girinimbine (56 μM; 12-48 h) also exhibits a time-dependent accumulation of the Sub-G0/G1 peak and induces G0/G1-phase arrest.[1] Moreover, Girinimbine shows potent antitrypanosomal activity, with an IC50 value of 10.16 μg/mL.[3] |
| In vivo | Girinimbine (10-100 mg/kg; orally gavage; once; Male ICR mice) pretreatment effectively reduces total leukocyte migration and lowers pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid, while Girinimbine (20 μg/mL; 24 h; zebrafish embryos) shows a significant distribution of apoptotic cells in embryos.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Girinimbine |
| Inhibitors Related | Neomycin sulfate | Stavudine | Dehydroacetic acid sodium | Ampicillin sodium | Kanamycin sulfate | Sodium 4-phenylbutyrate | Sulfamethoxazole sodium | Doxycycline | Tributyrin | Dimethyl sulfoxide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States