Product Details
| Product Name:
Gartanin |
CAS No.:
33390-42-0 |
| Purity:
99.85% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Gartanin |
| Description | Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±signaling pathways. |
| In vitro | The interaction of Gartanin with the ligand-binding domain was characterized using a fluorescence polarization cell-free assay and cell-based FRET assay. Western blot analysis identified modulation of ER stress markers (BiP, PERK, IRE1, and CHOP) along with androgen receptor degradation. A computation simulation was performed to identify possible orientations of Gartanin with the ligand-binding domain. Utilizing a cell-free and cell-based FRET assays Gartanin was found to interact with the ligand-binding domain through a solely antagonist interaction. Interestingly, inhibition of CHOP, a critical component of the ER stress pathway, was observed to stabilize AR[1] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (126.13 mM)
|
| Keywords | Fungal | Autophagy | inhibit | Gartanin | Inhibitor |
| Inhibitors Related | (S)-(+)-Ibuprofen | Astragaloside IV | Navitoclax | Taurochenodeoxycholic Acid | Tauroursodeoxycholate sodium | (-)-Bornyl acetate | Venetoclax | (Iso)-Z-VAD(OMe)-FMK | Anisomycin | Tauroursodeoxycholate | Bentamapimod | Boc-Asp(OMe)-fluoromethyl ketone |
| Related Compound Libraries | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Neurodegenerative Disease Compound Library | Selected Plant-Sourced Compound Library | Anti-Fungal Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1g |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-01-06 |
United States