Folic acid NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Folic acid | CAS No.: 59-30-3 |
| Purity: 99.27% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Folic acid |
| Description | Folic acid (Vitamin B9) is a vitamin B9 that is essential for the synthesis of DNA/RNA and for the production and maintenance of new cells. Folic acid deficiency can lead to anemia, neural tube closure defects, tumors, aging, and other diseases. |
| Cell Research | To determine the effect of FA supplementation on BRCA1 and BRCA2 mRNA expression, all cell lines were treated with 0, 25, 50, 75, or 100 nmol/L FA for 72 hours before harvesting in TRI Reagent according to the manufacturer’s instructions. (Only for Reference) |
| In vitro | METHODS: HUVEC cells were treated with Folic acid (2.5-100 μM) for 48 h. Cell proliferation was detected using xCELLigence RTCA real-time cell analyzer. RESULTS: Folic acid increased cell proliferation in the HUVEC cell line using a cytometric index to determine the EC50 dose of 50 μL.[1] METHODS: Neural tube explants were treated with Folic acid (90 μM) for 3 h and morphology was observed using microscopy. RESULTS: In the presence of Folic acid, cell migration from the neural tube explants was detected in 80% of the cultures within 2-3 h. The first cell to leave the initial explant was the first cell to leave the neural tube explant. The first cells leaving the initial explants were tightly organized neuroepithelial cells and the explants were firmly attached to the fibronectin layer. [2] |
| In vivo | METHODS: To investigate the role of Folic acid (1-100 mg/kg) in a behavioral model of depression, Swiss mice were administered Folic acid (1-100 mg/kg) in a single gavage dose and subjected to the forced swimming test (FST) and tail suspension test (TST). RESULTS: Oral administration of Folic acid reduced immobilization time in the FST (50-100 mg/kg) and TST (10-50 mg/kg). Folic acid produces antidepressant-like effects in the FST and TST. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (5.66 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 25 mg/mL (56.63 mM), Sonication is recommended. |
| Keywords | ntidepressant-like | nutrient | Endogenous Metabolite | folic deficiency | Folic acid | Vitamin B-9 | DNA/RNA Synthesis | inhibit | neural tube defects | Vitamin B 9 | Inhibitor |
| Related Compound Libraries | Bioactive Compound Library | Natural Product Library | Tobacco Monomer Library | Microbial Natural Product Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | FDA-Approved Drug Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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