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Postion:Product Catalog >(E/Z)-SIB-1893
(E/Z)-SIB-1893
  • (E/Z)-SIB-1893

(E/Z)-SIB-1893 NEW

Price $67 $118 $247
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: (E/Z)-SIB-1893 CAS No.: 6266-99-5
Purity: 99.92% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name(E/Z)-SIB-1893
Description(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893. (E)-SIB-1893 is a selective, noncompetitive mGluR5 antagonist with anticonvulsant activity .
In vitroWe investigated the role of mGluR5 in acute NMDA and glutamate-mediated neurodegeneration in cultured rat cortical cells using the mGluR5 antagonists SIB-1893 (20 or 200 μM; rat cortical cells) and found that they provide significant protection.[4]
In vivo(E/Z)-SIB-1893 (10, 20, and 30 mg/kg; i.p.; 0-180 min) considerably lowered the body temperature in animals at 90, 120, and 180 min after its systemic injection of 30 mg/kg. In contrast, the drug at 10 and 20 mg/kg remained without effect on the body temperature in rats. Based on our preclinical study, one can conclude that (E/Z)-SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner.[1] SIB 1893 (10 and 20 mg/kg; mice; i.p.) did not affect the protective action of valproate, ethosuximide, phenobarbital, and clonazepam in this test. The combined treatment of SIB 1893 with conventional antiepileptic drugs did not lead to motor impairment. Long-term memory disturbances were observed only in the case of the combination of SIB 1893 with phenobarbital.[2]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 90.0 mg/mL (460.9 mM), Sonication is recommended.
Keywords(E/Z)-SIB1893 | (E/Z)-SIB 1893 | SIB1893 | SIB-1893 | (E/Z)-SIB-1893
Inhibitors RelatedIDRA-21 | Topiramate | Decanoic Acid | Urethane | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Piracetam | O-Phospho-L-serine | Memantine hydrochloride
Related Compound LibrariesBioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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