
ERCC1-XPF-IN-2 NEW
Price | $34 | $55 | $97 |
Package | 2mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: ERCC1-XPF-IN-2 | CAS No.: 1808986-37-9 |
Purity: 98.34% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | ERCC1-XPF-IN-2 |
Description | ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1]. |
In vitro | ERCC1-XPF-IN-2 (compound 13) (0-100 μM) exhibits DNase I and FEN-1 activity with IC50s of >100 μM, and shows binding kinetics with a Kd of ~30 μM. It is non-toxic to Hep-G2 cells at 10 μM and has short microsomal half-lives in mouse (23 min) and human (28 min). At 0-60 μM for 24 hours, it inhibits nucleotide excision repair (NER) with an IC50 of 15.6 μM in A375 cells and enhances cisplatin activity without toxicity. Additionally, at 10 μM for 6 hours, it delays DNA repair, indicated by an increase in γH2AX foci per cell[1]. |
Storage | Shipping with blue ice. |
Solubility Information | DMSO : 225.0 mg/mL (689.8 mM) |
Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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