Encequidar mesylate NEW
| Price | $56 | $81 | $157 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Encequidar mesylate | CAS No.: 849675-87-2 |
| Purity: 99.67% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Encequidar mesylate |
| Description | Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor. |
| In vitro | Administration of Encequidar at concentrations of 0.1 or 1 nM resulted in a reduction of cell survival by 20% and 42% upon exposure to 100 nM and 1000 nM of NSC 125973, respectively [2]. |
| In vivo | When administered simultaneously, Encequidar demonstrates increased plasma concentrations with the microcapsule formulation compared to the powder, showing notable differences from 1 to 2 hours. The microcapsule formulation achieves a 1.7-fold quicker Tmax and a 1.6-fold greater AUC value than the powder (2.5±0.6 vs. 4.3±0.9 hours; 107.7±20.1 vs. 64.3±18.0 h ng/mL), indicating faster and more efficient absorption. This enhanced absorption of Encequidar in microcapsule format is likely attributed to its improved aqueous solubility and dissolution rates, facilitated by the conversion from crystalline to amorphous form and the reduction in particle size [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (70.08 mM), Sonication is recommended. |
| Keywords | HM30181A | HM 30181 Mesylate | HM30181 Mesylate | HM 30181 | Encequidar Mesylate | Encequidar mesylate | HM30181 | MDR1 | ABCB1 | HM-30181 Mesylate | P-gp | inhibit | CD243 | P-glycoprotein | Cluster of differentiation 243 | HM-30181 | Inhibitor | HM30181A Mesylate | Encequidar | Pgp | Multidrug resistance protein 1 |
| Inhibitors Related | Atazanavir | Selamectin | Verapamil hydrochloride | Glibenclamide | Verapamil | Polyoxyethylene stearate | Muscone | Elacridar | P-gp inhibitor 1 | Piperine | Cinchonine | Atazanavir sulfate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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