Product Details
Product Name:
EN3356 |
CAS No.:
1429329-63-4 |
Purity:
97.47% |
Supply Ability:
10g |
Release date:
2024/11/17 |
Product Introduction
Bioactivity
名稱 | EN3356 |
描述 | EN3356 is an orally available and selective inhibitor of steroidal 17-alpha-hydroxylase/C17,20 cleavage enzyme (CYP17A1 or CYP17), a non-steroidal cleavage enzyme-selective compound with potential anti-androgenic and anti-tumor activity. |
體內活性 | EN3356 (50, 100, 200 mg; oral; escalating doses; once a day) was well tolerated, and drug-related AEs were CTCAE Gr 1 and 2 incl. myalgia, anorexia, flushing, hot flashes, and presyncope. Excellent systemic exposure was observed at both 50 mg and 100 mg QD regimens (Cmax, Ctrough, and AUCτ at 100 mg QD were 3.5 uM, 1.8 uM, and 52 uM.h, respectively). The Phase 1 clinical study results to date show that EN3356 is safe and well tolerated at doses of up to 100 mg daily.[1] |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 7.5 mg/mL (24.97 mM), Sonication is recommended.
|
關鍵字 | ASN 001 | EN-3356 | AS N-001 | AS N 001 | EN 3356 | EN3356 | ASN001 |
相關產品 | Tebuconazole | 1-Ethynylnaphthalene | Diflubenzuron | Apigenin | Gemfibrozil | Fenofibrate | 1-Aminobenzotriazole | Methoxsalen | Naringin | Naringenin | Tauroursodeoxycholate | Doxepin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |