Echinatin NEW
| Price | $31 | $64 | $113 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: Echinatin | CAS No.: 34221-41-5 |
| Purity: 99.61% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | Echinatin |
| 描述 | Echinatin (Retrochalcone) is extracted from licorice and is a natural chalcone. Echinatin has a wide range of biological activities including hepatoprotective, anti-inflammatory, anti-bacterial infections, and attenuates lung damage. |
| 體外活性 | METHODS: Esophageal squamous cell carcinoma cells KYSE30 and KYSE270 were treated with Echinatin (10-40 μM) for 1-5 days and cell viability was measured by CCK-8 assay. RESULTS: Echinatin significantly inhibited cell proliferation in a dose- and time-dependent manner. [1] METHODS: Human osteosarcoma cells 143B and MG63 were treated with Echinatin (30-50 μM) for 24 h. Cell cycle was measured by Flow cytometry. RESULTS: Echinatin significantly increased the percentage of osteosarcoma cells in the S phase of the cell cycle. [2] |
| 體內(nèi)活性 | METHODS: To test the antitumor activity in vivo, Echinatin (20-50 mg/kg) was administered by gavage to nude mice bearing KYSE270 xenografts every two days for 14 days. RESULTS: Tumor load was significantly suppressed, with a 57% and 48% reduction in the groups treated with 20 and 50 mg/kg Echinatin, respectively.Echinatin inhibited the AKT/mTOR pathway, as evidenced by a reduction in the expression levels of p-AKT and p-mTOR. [1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.9 mg/mL (18.13 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. Chloroform : Soluble DMSO : 20 mg/mL (74 mM) |
| 關(guān)鍵字 | inhibit | Echinatin | Inhibitor |
| 相關(guān)產(chǎn)品 | Tempo | Cycloolivil | Sodium 4-aminosalicylate dihydrate | Rubiadin | Edaravone | AFMK | Maclurin | Retusin | Peonidin-3-O-glucoside chloride | Isomangiferin | Rebamipide | Cyclo(L-Phe-L-Pro) |
| 相關(guān)庫 | 黃酮類天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 植物來源化合物庫 | 中藥抗炎分子庫 | 高通量篩選天然產(chǎn)物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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