Product Details
| Product Name:
DT-6 |
CAS No.:
2414315-95-8 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | DT-6 |
| Description | DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing potential for cancer research applications [1]. |
| In vitro | DT-6, at concentrations ranging from 0.1-50 μM for 0-18 hours, reduced the protein expression of TGF-β1 in various cell lines, including THP-1, BV2, A549, MCF-7, U87, and HepG2 [1]. Additionally, a 50 μM dose of DT-6 over a 24-hour period decreased the secretion of TGF-β1 in M2 macrophages cultured in conditioned medium (CM) [1]. Furthermore, at 20 μM and 50 μM for 24 and 48 hours, DT-6 inhibited the ability of M2 macrophages to induce epithelial-to-mesenchymal transition (EMT) and the invasive migration of cancer cells by reducing the secretion of TGF-β1 [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | Monocrotaline | SB-431542 | DMH-1 | RepSox | Chromenone 1 | LY-364947 | BMP signaling agonist sb4 | Pirfenidone | A 83-01 | Galunisertib | Alantolactone | Pentabromophenol |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
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Price |
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Suppliers |
Update time |
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$1610.00/50mg |
VIP3Y
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TargetMol Chemicals Inc.
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2024-10-28 |
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$0.00/1KG |
VIP3Y
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Shanghai Qyubiotech Co., Ltd.
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2023-11-08 |
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$0.00/100mg |
|
Hefei Huana Biomedical Technology Co.,Ltd.
|
2023-03-09 |
United States