Product Details
| Product Name:
Dehydroabietinol |
CAS No.:
3772-55-2 |
| Purity:
99.36% |
Supply Ability:
10g |
| Release date:
2025/05/27 |
Product Introduction
Bioactivity
| Name | Dehydroabietinol |
| Description | Dehydroabietinol (Pomiferin A) inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). |
| In vitro | Dehydroabietinol isolated from Hyptis suaveolens (L.) Poit. was found to inhibit growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). However, erythrocytes exposed to Dehydroabietinol were transformed in a dose-dependent manner towards spherostomatocytic forms with concomitant formation of endovesicles, as disclosed by transmission electron microscopy. The erythrocyte shape alterations caused by Dehydroabietinol correlated well with its apparent IC 50 value. CONCLUSIONS: Thus, Dehydroabietinol incorporates into the erythrocyte membrane, and since invasion and survival of Plasmodium parasites is known to depend on the function of the erythrocyte membrane, the observed antiplasmodial effect of Dehydroabietinol is presumably an indirect effect on the host cell. Because of these findings, microscopic investigations should be generally used to support claims of antimalarial effects of apolar natural products[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Dehydroabietinol | Antifection |
| Inhibitors Related | Miconazole | 1-Docosanol | Ganciclovir sodium | Metronidazole | L-Lysine | Chlorhexidine dihydrochloride | Clotrimazole | Idoxuridine | Chlorhexidine | Fluconazole | Chlorhexidine diacetate | Ganciclovir |
| Related Compound Libraries | Anti-Parasitic Compound Library | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Rare Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
-
CAS:15592-37-7
$113.00 / 1mg
-
CAS:3184-13-2
$30.00 / 50mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States