Cutamesine dihydrochloride NEW
| Price | $37 | $57 | $102 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Cutamesine dihydrochloride | CAS No.: 165377-44-6 |
| Purity: 99% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Cutamesine dihydrochloride |
| Description | Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. In a rat model of experimental stroke, it enhances brain plasticity and sensorimotor function. |
| Cell Research | The NSC34 cells are seeded at a density of 7000 cells per well into 96-well plates with D-MEM and transfected using Lipofectamine 2000 mixed with 2 μg /mL of plasmid vector in D-MEM for 6 h. After 6 h, the cell-culture medium is replaced with fresh D-MEM and culture and allowed to proceed for a further 42 h. The cells are then transferred to serum-free D-MEM and immediately treated with SA4503 at a final concentration of 1, 3, or 10 nM[2]. |
| In vitro | The sigma receptor is implicated in various central nervous system diseases. SA4503, a potent σ1 receptor agonist, exhibits a 103-fold higher affinity for σ1 (IC50=17.4 nM) than σ2 (IC50=1,784 nM) in guinea pig brain membranes and is 14-fold selective for σ1 (Ki=4.6 nM) over σ2 (Ki=63.1 nM) in guinea pig brain homogenates[1]. SA4503 protects motor neuron NSC34 cells against superoxide dismutase 1 and serum-free neurotoxicity, upregulating phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2[2], while reducing MAPK/ERK pathway activation and down-regulating the ionotropic glutamate receptor, GluR1[3]. |
| In vivo | SA4503 extends the survival time in the SOD1 g93A mice[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mg/mL (22.65 mM), Sonication and heating are recommended. |
| Keywords | Sigma Receptor | AGY 94806 Dihydrochloride | SA-4503 Dihydrochloride | SA 4503 | Cutamesine Dihydrochloride | Cutamesine dihydrochloride | AGY94806 | AGY 94806 | AGY94806 Dihydrochloride | AGY-94806 Dihydrochloride | inhibit | Inhibitor | SA4503 | SA4503 Dihydrochloride | SA 4503 Dihydrochloride | AGY-94806 | SA-4503 | Cutamesine |
| Inhibitors Related | KB-5492 free base | Blarcamesine hydrochloride | Amitriptyline hydrochloride | S1R agonist 2 | Ditolylguanidine | 4-PPBP maleate | Sigma-1 receptor antagonist 1 | Glycerol phenylbutyrate | KSK67 | AB21 HCl |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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