Product Details
| Product Name:
Cindunistat |
CAS No.:
364067-22-1 |
| Purity:
99.22% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Cindunistat |
| Description | Cindunistat (free base) is an orally available selective iNOS inhibitor for the study of arthritis. |
| In vivo | In 1457 patients (50 mg/day, n=485; 200 mg/day, n=486; placebo, n=486), 1048 (71.9%) completed the study. 56% had KLG3. In KLG2 patients, JSN after 48 weeks was lower with Cindunistat 50 mg/day versus placebo (p=0.032). Least-squares mean±SE JSN with Cindunistat 50 mg/day ( -0.048±0.028 mm) and 200 mg/day (-0.062±0.028 mm) were 59.9% (95% CI 6.8% to 106.9%) and 48.7% (95% CI -8.4% to 93.9%) of a placebo, improvement was not maintained at 96 weeks. No improvement was observed for KLG3 patients at either time point. Cindunistat did not improve joint pain or function but was generally well tolerated. Cindunistat (50 or 200 mg/day) did not slow the rate of JSN versus placebo. After 48 weeks, KLG2 patients showed less JSN.[1] |
| Storage | store under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (250.8 mM)
|
| Keywords | Cindunistat | SD 6010 |
| Inhibitors Related | Miconazole | Aminoguanidine hydrochloride | L-NAME hydrochloride | EIT hydrobromide | 3-Bromo-7-nitroindazole | Dexamethasone acetate | S-Methylisothiourea sulfate | Cannabigerol | 1400W dihydrochloride | Flavone | S-(2-aminoethyl) Isothiourea (dihydrobromide) | Diallyl disulfide |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$2420.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-11-11 |
United States