Cidofovir
Price | Get Latest Price |
Package | 200kg |
Min. Order: | 20kg |
Supply Ability: | 20 tons |
Update Time: | 2024-11-08 |
Product Details
Product Name: Cidofovir | CAS No.: 113852-37-2 |
Min. Order: 20kg | Purity: 99% |
Supply Ability: 20 tons | Release date: 2024/11/08 |
113852-37-2 - Physico-chemical Properties
Molecular Formula | C8H14N3O6P |
Molar Mass | 279.19 |
Density | 1.76±0.1 g/cm3(Predicted) |
Melting Point | 260° (dec) |
Boling Point | 609.5±65.0 °C(Predicted) |
Specific Rotation(α) | D20 -97.3° (c = 0.80 in water) |
Flash Point | 322.4°C |
Solubility | 25°C: DMSO <1 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL |
Vapor Presure | 2.11E-17mmHg at 25°C |
Appearance | Powder |
pKa | 2.29±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
Refractive Index | 1.656 |
MDL | MFCD17215968 |
Physical and Chemical Properties | Bulky white powder, melting point 260 ° C (decomposition). [Α]{D}^ 20-97.3 °(C = 0.80, water). Monohydrate: UV absorption maximum (Ph = 2):279nm (λ13000). |
Use | Antiviral drugs |
In vitro study | Cidofovir treatment of cultured cells inhibits human cytomegalovirus (HCMV) infection. Cidofovir inhibits cytomegalovirus (CMV) plaque formation even when added to cells 48 hours after infection, the IC50 values for Davis and AD-169 strains were 0.9 μg/mL and 1.6 μg/mL, respectively. Cidofovir also Inhibits Herpes simplex virus infection. In addition, Cidofovir acts on monkey kidney cells, inhibits HSV-1-induced cell fusion, and also inhibits the expression of HSV-1-specific proteins and the synthesis of viral DNA. |
In vivo study | Cidofovir, administered subcutaneously to infected guinea pigs at a dose of 5 mg/kg daily for 5 days, significantly reduced viral infectivity in the blood, spleen, lung, and salivary glands. Cidofovir treatment of infected animals significantly reduced lymphocytosis and the average tissue index of the spleen. Cidofovir acts on hairless mice infected intradermally with HSV-1 or HSV-2, suppressing all clinical manifestations (skin lesions, paralysis of hind legs, and death). The most remarkable feature of Cidofovir is that it is administered alone until the 4th day after infection and is also significantly resistant to HSV-1 or HSV-2 infections. Cidofovir acts on C57B16/J mice subcutaneously transplanted with mouse melanoma B16 cells to inhibit the growth of the resulting highly aggressive melanoma. |
Company Profile Introduction
Qingdao RENAS Polymer Material Co., Ltd. is located in E.T.D.Z of Qingdao China, it is one integrated company, devoted to environmental protection and low carbon energy, new materials introducing, research and development, which aims to offer the best quality products and service to the domestic and foreign markets. We maintain a good partnership with many word famous chemical manufacturers. Integrated of advanced products and technology of domestic and foreign manufacturers, we could customize the products matching scheme for various industries customers, and offer the comprehensive solution to customers.
We have unique technology and product advantages, especial in the field of rubber additive, acrylic monomer, solvent, pharmaceutical intermediates and ink coating resin.
We have a professional management, business and technical team, and have passed the ISO9001 system certification. We have passed the fast response ability and reliable product quality. With the mission of "steady development and dedication to China", we adhere to the business philosophy of "the interests of users are our most fundamental interests, and the needs of users are our needs". Through concept innovation, management innovation, technical innovation, market innovation, and product innovation, Strive to make the company an excellent supplier in the field of global chemical materials.
We welcome friends all over the world to visit and negotiate with us. We sincerely hope to expand our trade and cooperation based on mutual benefits and realize the mutual prosperity and development.
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- Since: 2010-04-27
- Address: No. 18 Qinhuangdao Road, E.T.D.Z of QINGDAO
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