cGAMP disodium NEW
| Price | $1458 | $2128 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: cGAMP disodium | CAS No.: 2407516-83-8 |
| Supply Ability: 10g | Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | cGAMP disodium |
| Description | cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I interferons and other immune mediators by activating interferon gene stimulator (STING). cGAMP disodium is a potent sublingual immune adjuvant that enables better immune function (serum anti-PA neutralization and airway secretions anti-PA SIgA response). |
| In vitro | cGAMP disodium directly activates mouse and human dendritic cells in in vitro experiments [1]. It promotes the antigen-specific proliferative capacity of mouse spleen cells [2]. Furthermore, cGAMP disodium induces the induction of antiviral state and the secretion of type I IFNs through activation of the endoplasmic reticulum (ER)-resident receptor STING [3]. cGAMP disodium causes fibroblasts from patients to exhibit increased transcription of IFNB1, which encodes interleukin-1 (IL1), interleukin-6 (IL6) or tumor necrosis factor (TNF) genes did not show a transcriptional increase [4]. |
| In vivo | The titers of OVA specific IgA, total IgG, IgG1 and IgG2c in the serum of female C57BL/6 (H-2b) mice were higher than those of OVA immunized mice after the injection of 5μg at 6-8 weeks of age. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | cGAMPdisodium | cGAMP disodium | cGAMP |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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