Cap-dependent endonuclease-IN-26 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Cap-dependent endonuclease-IN-26 | CAS No.: 1370238-26-8 |
| Supply Ability: 10g | Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Cap-dependent endonuclease-IN-26 |
| Description | Cap-dependent endonuclease-IN-26, a potent inhibitor of cap-dependent endonuclease (CEN) with an IC50 of 286 nM, exhibits significant antiviral activity against a broad spectrum of influenza A and B strains [1]. |
| In vitro | Cap-dependent endonuclease-IN-26 (compound 2v) demonstrates a broad antiviral spectrum effective against various influenza strains, including H1N1 (rgA/WSN/33, rgA/WSN/33-NA/H274Y, A/PR/8/34), H3N2 (A/Victoria/3/75, A/HongKong/8/68), oseltamivir-resistant, clinically isolated strains, and influenza B (Hong Kong/5/72, Maryland/1/59), with EC50 values of 165.1 nM, 80.4 nM, 183.0 nM, 828.8 nM, 301.5 nM, 124.3 nM, and 176.0 nM, respectively [1]. |
| In vivo | In rats, Cap-dependent endonuclease-IN-26 (compound 2v) demonstrates favorable in vivo clearance rates at 10.9 mL/min/kg [1]. Administered intravenously at doses ranging from 0.08-10 mg/kg once daily for a day in a mouse influenza B (B/Maryland/1/59) model, compound 2v exhibits dose-dependent efficacy in an immediate treatment scenario [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $636.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-05-13 | |
| $0.00/5mg |
VIP1Y
|
Guangzhou Tosun Pharmaceutical Ltd
|
2025-02-11 | |
| $0.00/10mg |
VIP2Y
|
ShenZhen H&D Pharmaceutical Technology Co., LTD
|
2024-06-28 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY