Busulfan
Price | Get Latest Price | ||
Package | 1kg | 5kg | 10kg |
Min. Order: | 1kg |
Supply Ability: | 1000 |
Update Time: | 2025-01-18 |
Product Details
Product Name: Busulfan | CAS No.: 55-98-1 |
Min. Order: 1kg | Purity: 98 |
Supply Ability: 1000 | Release date: 2025/01/18 |
Product Name: Busulfan
Synonyms: BUSULFAN;tetramethylene bis(methanesulfonate);myleran;busulfex;busulphan;1,4-dimethanesulfonoxybutane;1,4-Bis(methyl sulfonoxy)butane;1,4-BUTANEDIOL DIMETHANESULFONATE
CAS: 55-98-1
MF: C6H14O6S2
MW: 246.3
EINECS: 200-250-2
Product Categories: MYLERAN;Antitumors for Research and Experimental Use;Biochemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;55-98-1
Chemically, busulfan is classified as an alkyl sulfonate. One or both of the methylsulfonate ester moieties can be displaced by the nucleophilic N7 of guanine, leading to monoalkylated and cross-linked DNA. The extent of alkyl sulfonate–mediated DNA interstrand cross-linking has been shown to vary with the length of the alkyl chain between sulfonate esters, with the tetramethylene-containing busulfan showing less interstrand cross-linking capability than hexamethylene, methylene, or octamethylene analogues. Intrastrand cross-linking also occurs, preferentially at 5′-GA-3′ but also at 5′-GG-3′ sequences. Alkylation of Cys sulfhydryl groups is yet another mechanism of cytotoxicity.
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