Brilliant Black BN NEW
| Price | $48 | $68 | $98 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-12 |
Product Details
| Product Name: Brilliant Black BN | CAS No.: 2519-30-4 |
| Supply Ability: 10g | Release date: 2025/07/12 |
Product Introduction
Bioactivity
| Name | Brilliant Black BN |
| Description | Brilliant Black BN (E 151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71 and its cellular uncoating factor cyclophilin A. |
| Cell Research | Resting cell dye decolorization experiment 1. Deep-sea isolates were transferred to fresh 250 mL-GYE broth, centrifuged and added to 20 mM Tris-HCl (pH 7.6) for resting cell assays. 2. Cells were grown in 10 mL tubes (final cell dry weight up to 5.20–5.38 g/L), then Brilliant Black BN was added to a final concentration of 100 mg/L, the tubes were gently inverted several times, and incubated at 30°C, taking care not to shake; 3. Samples (200 μL) were collected regularly from 0 to 3 hours, immediately boiled in a dry heat bath for 5 minutes, and then centrifuged (13,000 g, 10 minutes); 4. The residual dye concentration of the supernatant was measured. |
| In vitro | Brilliant black BN inhibited the infection EV71 -GFP at a concentration of 300 μM. Brilliant black BN exhibits the inhibition of EV71 -GFP as a dose-dependent manner in infected RD cells (IC50: 10.1 μM). Brilliant black BN is able to inhibit all tested 28 EV71, CVA16, and CVA6 strains. In rhabdomyosarcoma cells, 50% inhibitory concentration 29 of the dye E151 for various strains of EV71 ranged from 2.39 μM to 28.12 μM, whereas its 50% cytotoxic concentration is 1870 μM [2]. |
| In vivo | Brilliant black BN (i.p.; 200 mg/kg; 14 days)exhibits mild illness with clinical scores less than 3 and subsequently recovered when compared with PBS-group. All E151 270 treated mice are completely protected throughout the experiment [2]. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 123 mg/mL (141.75 mM), Sonication is recommended. |
| Keywords | VirusProtease | Virus Protease | various strains of EV71 | Rhinovirus | Inhibitor | inhibit | HRVs | HRV | HFMD | HEVs | HEV | EV71,infection | Enterovirus | E-151 | E151 | disease | Brilliant Black BN | antiviral,food | additive,contagious |
| Inhibitors Related | EIDD-1931 | Phenytoin sodium | Aspirin | Anthraquinone | Vorinostat | L-Lysine | 2-Phenylethanol | L-Lysine hydrochloride | (-)-Epicatechin gallate | (-)-α-Pinene | Artesunate | 4-Phenylbutyric acid |
| Related Compound Libraries | Cosmetic Ingredient Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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