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Postion:Product Catalog >BMS 195614
BMS 195614
  • BMS 195614

BMS 195614 NEW

Price $181 $418 $619
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: BMS 195614 CAS No.: 253310-42-8
Purity: 97.7% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameBMS 195614
DescriptionBMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.
In vitroBMS 195614 reversed the induction effect of selective RARα agonists, AM580, AM80 and BMS 194753 on differentiation of the acute promyelocytic leukemia cell lines, NB4 and HL60 [1]. Treatment with retinoic acid (RA) (1 uM) for 72 hrs significantly reduced T47D breast cancer cells migration. But RA in combination with BMS 195614 did not affect the cell movement [2]. In cells of a bovine stromal-vascular fraction from intramuscular fat, BMS 195614 significantly diminished the anti-adipogenic effect of ATRA [3].
In vivoBMS 195614 displayed poor in vivo activity in mice when administered orally. Treatment with BMS 195614 at oral doses for 1 month showed no inhibition to spermatogenesis [4]. Oral administration of BMS 195614 did not suppress spermatogenesis in mice [5].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 10.1 mg/mL (22.5 mM)
KeywordsBMS 195614 | BMS-614 | BMS195614 | BMS 614 | BMS-195614
Inhibitors RelatedIsotretinoin | Oxybenzone | MSU-42011 | Tazarotene | Etodolac | KCL-286 | ER 50891 | Acitretin | Tamibarotene | Bexarotene | TTNPB | K-8012
Related Compound LibrariesNuclear Receptor Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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