Product Details
| Product Name:
Atpenin A5 |
CAS No.:
119509-24-9 |
| Purity:
97.33% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Atpenin A5 |
| Description | Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), as well as an effective mKATP channel agonist and cardioprotective agent [1]. |
| In vitro | Atpenin A5 effectively inhibits submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, exhibiting IC50 values of 8.3 nM, 9.3 nM, and 8.5 nM, respectively. It acts as a potent, specific inhibitor of complex II. Moreover, at a concentration of 1 nM, Atpenin A5 (AA5) activates the mitochondrial ATP-sensitive potassium (mKATP) channel and offers protection against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes[1]. |
| In vivo | Atpenin A5, a potent succinate dehydrogenase (SDH) inhibitor, promotes cardiomyocyte mitosis and regeneration in the postnatal heart following myocardial infarction (MI). Mice injected with Atpenin A5 (100 μg/kg) showed increased myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls[2]. |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (273.04 mM), Sonication is recommended.
|
| Keywords | Atpenin A5 | preconditioning | sensitive | mKATP | Atpenin A 5 | ischemia | potassium | complex II | Inhibitor | cardioprotective | channel | mitochondrial | Potassium Channel | KcsA | ATP | inhibit | reperfusion | Atpenin A-5 |
| Inhibitors Related | Minoxidil sulfate | Halothane | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Indapamide |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Neuroprotective Compound Library | Microbial Natural Product Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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